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產(chǎn)品規(guī)格
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BN41389R-100ul
100ul
￥2360.00
交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
BN41389R-200ul
200ul
￥3490.00
交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
| 英文名稱 | TNNI3K |
| 中文名稱 | 絲氨酸/蘇氨酸蛋白激酶TNN13K抗體 |
| 別 名 | Cardiac ankyrin repeat kinase; CARK; MGC142099; MGC33828; Serine/threonine protein kinase TNN13K; Serine/threonine-protein kinase TNNI3K; TNI3K_HUMAN; TNNI3 interacting kinase; TNNI3-interacting kinase; Tnni3k. |
| 研究領(lǐng)域 | 腫瘤 心血管 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Rat, (predicted: Mouse, Chicken, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 93kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TNNI3K:1-100/835 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | TNNI3K, also known as CARK, is a 936 amino acid serine/threonine-protein kinase that is highly expressed in heart. Overexpression of TNNI3K leads to improved cardiac function by enhancing beating frequency and increasing contractile force and epinephrine response. TNNI3K suppresses phosphorylation of cardiac troponin I and p38/JNK-mediated apoptosis, therefore protecting the myocardium from ischemic injury. Administration of TNNI3K to mice with myocardial infarction improves cardiac performance and attentuates ventricular remodeling, suggesting that TNNI3K could be a promising target in the treatment of cardiac diseases. There are four isoforms of TNNI3K that are produced as a result of alternative splicing events. Function: May play a role in cardiac physiology. Subunit: Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB. Subcellular Location: Nucleus. Cytoplasm. Expressed at lower levels in the cytoplasm. Tissue Specificity: Highly expressed in both adult and fetal heart. Post-translational modifications: Autophosphorylated. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 10 ANK repeats. Contains 1 protein kinase domain. SWISS: Q59H18 Gene ID: 51086 Database links: Entrez Gene: 51086 Human Entrez Gene: 435766 Mouse SwissProt: Q59H18 Human SwissProt: Q5GIG6 Mouse Unigene: 729320 Human Unigene: 210428 Mouse Unigene: 3434 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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